Hyperphagia and Obesity in Female Mice Lacking Tissue Inhibitor of Metalloproteinase-1
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چکیده
منابع مشابه
Deficiency of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) impairs nutritionally induced obesity in mice.
Tissue inhibitor of matrix metalloproteinase-1 deficient (TIMP-1(-/-)) mice and wild-type (TIMP-1(+/+)) controls were kept on a standard (SFD) or a high fat diet (HFD) for 15 weeks. At the time of sacrifice, TIMP-1(-/-) mice on HFD had a significantly lower body weight (29 +/- 1.5 versus 41 +/- 1.8 g, p <0.005), and significantly less subcutaneous (0.81 +/- 0.19 versus 1.78 +/- 0.21 g, p <0.05)...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2008
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2008-1409